This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinesis, receptors and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contributions of scientists early in their career, who have made an excellent contribution to the institute.
International Review of Cytology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address cell biology of membrane trafficking in human disease; the biology of the gaucher cell; intracellular signals and events activated by cytokines of the TNF superfamily; cellular and molecular biology of orphan G-protein coupled receptors; organization and function of the actin; cytoskeleton in developing root cells.
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.
This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.
The quantity of information available about membrane proteins is now too large for any one person to be familiar with anything but a very small part of the primary literature. A series of volumes concentrating on molecular aspects of biological membranes therefore seems timely. The hope is that, when complete, these volumes will provide a convenient introduction to the study of a wide range of membrane functions.
The Second World War put an end to America's historical isolation from international power politics, and so also to the long-standing American defiance of the Realist ideology that shaped Old World affairs. The advent of transoceanic military technologies, now wielded by menacing states such as Nazi Germany and the Soviet Union, made Americans more receptive to the Realist idea that international relations is about fear and survival. The American Realists Reinhold Niebuhr, Hans Morgenthau, and Kenneth Waltz developed a modern strategic framework that sought to introduce American leaders and the educated public to these harsher realities of international politics. They emphasized a clear-eyed, cold approach to the play of interests, egotism, and the drive for power in world affairs -- a struggle in which the threat of major war remained, in the end, the only legitimate currency.
Yet even as Americans began to accept this new Realism, thermonuclear weaponry threatened to make it absurd. A major war to defend the nation might result in its total destruction; a thermonuclear war leading to the death of hundreds of millions of citizens seemed an unusual way to preserve American survival. This dilemma became central to the Realist understanding of Niebuhr, Morgenthau, and Waltz. How could a Realist approach to international politics and war be sustained in the face of possible global annihilation?
"Glimmer of a New Leviathan" is the engrossing story of how the three chief architects of an influential ideology struggled with the implications of their own creation. It offers crucial historical context for contemporary debates about weapons of mass destruction and the post-Cold War international order.
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