This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants.
Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets.
In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.
The steroid or nuclear receptor superfamily is an important group of transcription factors that is studied by a large and varied number of basic and clinical researchers. Nuclear Receptors: A Practical Approach provides these researchers an invaluable guide to do so. With an international list of contributors and examples of over 70 tried and true protocols, this book offers substantial insight into the growing family of biologically important receptors. Its chapters address a variety of factors, including the evolutionary biology of the superfamily and how to clone and characterize new receptors. Also addressed are topics such as identification of the ligands of novel receptors, the kinetic analysis of receptor interactions, and the functional characterization of coactivators using microinjection. Various sections throughout the book cover receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. The book concludes with a description of yeast as a model system for looking at receptor function, and the final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a useful tool for any researcher studying members of the superfamily, and it is a must for all biomedical researchers.
This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.
This collection of literature attempts to compile many of the classic works that have stood the test of time and offer them at a reduced, affordable price, in an attractive volume so that everyone can enjoy them.
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